Gene therapy with adeno-associated virus (AAV)-based vectors shows great promise for the gene therapeutic treatment of a broad array of diseases.In fact, the treatment of genetic diseases with AAV vectors is currently the only in vivo gene therapy approach that is approved by the US Swimwear Food and Drug Administration (FDA).Unfortunately, pre-exi
Stroke is a leading cause of death and disability in both developed and developing countries.Limited information is available, in South Africa, on the epidemiological profile of stroke survivors requiring rehabilitation.A descriptive study was therefore undertaken to compile, amongst others the demographic and medical profile of stroke patients att
Abstract Background Our purpose is to develop a testable biological hypothesis to explain the known increased risk of breast cancer associated with extensive percent mammographic density (PMD), and to reconcile the apparent paradox that although PMD decreases with increasing age, breast cancer incidence increases.Methods We used the Moolgavkar mode
The potassium channel Kv1.3, involved in several important pathologies, is the target of a family of psoralen-based drugs whose mechanism of action is not fully understood.Here we provide evidence for a physical interaction of the mitochondria-located Kv1.3 (mtKv1.3) and Complex I of the respiratory chain and show that this proximity underlies the